This review addresses a critical public health issue: the impact of folic acid, both alone and in combination with other nutrients, on cognitive impairment and Alzheimer’s Disease. Folic acid is essential, and its deficiency is linked to neurocognitive dysfunctions, often due to hyperhomocysteinemia—an independent risk factor for cardiovascular and cerebrovascular diseases, including cognitive impairment and Alzheimer’s Disease. This review systematically analyzes various dietary intervention studies to evaluate the role of folic acid supplementation in these neurological conditions, focusing on the cognitive and biochemical markers used to assess disease progression.
The evidence compiled in this review suggests potential benefits of vitamin supplementation, particularly folic acid, in managing cognitive impairment and Alzheimer’s Disease, which are especially pertinent to the aging population and overall quality of life. However, it also underscores the need for more research to conclusively establish these findings. The review provides valuable insights for healthcare professionals into the potential therapeutic role of folic acid and its combinations with other vitamins, emphasizing the importance of dietary interventions in managing cognitive pathologies associated with aging.
Puga, A. M., Ruperto, M., Samaniego-Vaesken, M. de L., Montero-Bravo, A., Partearroyo, T., & Varela-Moreiras, G. (2021). Effects of Supplementation with Folic Acid and Its Combinations with Other Nutrients on Cognitive Impairment and Alzheimer’s Disease: A Narrative Review. Nutrients, 13(9), 2966.