Harnessing Hydrolyzed Collagen for Enhancing Muscle Mass in the Elderly

Hydrolyzed collagen, a highly bioavailable form of protein, has garnered significant attention for its potential benefits in muscle mass enhancement among the elderly.

A randomized controlled trial by Zdzieblik et al. (2021) in “International Journal of Environmental Research and Public Health” revealed that specific collagen peptides combined with resistance training significantly improved body composition and muscle strength in middle-aged, untrained men (Zdzieblik et al., 2021). Similarly, Brook et al. (2021) in “Clinical Nutrition” found that a blend of collagen protein hydrolysate and milk protein stimulated muscle anabolism equivalently to milk protein alone in older men (Brook et al., 2021).

Oertzen-Hagemann et al. (2019) in “Nutrients” demonstrated that collagen peptide supplementation, combined with resistance exercise, influenced the protein composition of skeletal muscle, leading to increases in muscle mass and strength in young men (Oertzen-Hagemann et al., 2019).

The benefits of hydrolyzed collagen extend beyond muscle mass. A study by Campos et al. (2021) in “Molecules” showed that oral supplementation with hydrolyzed fish cartilage improved skin health (Campos et al., 2021). Additionally, Chotphruethipong et al. (2021) in “Foods” found that hydrolyzed collagen from defatted sea bass skin positively affected osteoblast proliferation and differentiation, suggesting a role in bone health (Chotphruethipong et al., 2021).

Research by Lee et al. (2023) in “Frontiers in Physiology” indicated that collagen hydrolysate supplementation influenced patellar tendon properties in female soccer players, suggesting potential benefits in high-impact sports (Lee et al., 2023).

The integration of hydrolyzed collagen into the diet, especially when combined with resistance training, offers a promising approach to counteract the loss of muscle mass and strength in the elderly. The highlighted studies underscore the potential of collagen supplementation in improving not only muscle mass but also overall health in older individuals.


Zdzieblik, D., Jendricke, P., Oesser, S., Gollhofer, A., & König, D. (2021). The Influence of Specific Bioactive Collagen Peptides on Body Composition and Muscle Strength in Middle-Aged, Untrained Men: A Randomized Controlled Trial. International Journal of Environmental Research and Public Health, 18.

Brook, M. S., Scaife, P., Bass, J. J., Cegielski, J., Watanabe, S., Wilkinson, D. J., Smith, K., Phillips, B. E., & Atherton, P. J. (2021). A collagen hydrolysate/milk protein-blend stimulates muscle anabolism equivalently to an isoenergetic milk protein-blend containing a greater quantity of essential amino acids in older men. Clinical Nutrition (Edinburgh, Scotland), 40(5), 4456-4464.

Oertzen-Hagemann, V., Kirmse, M., Eggers, B., Pfeiffer, K., Marcus, K., de Marées, M., & Platen, P. (2019). Effects of 12 Weeks of Hypertrophy Resistance Exercise Training Combined with Collagen Peptide Supplementation on the Skeletal Muscle Proteome in Recreationally Active Men. Nutrients, 11(5), 1072.

Campos, P. M., Barboza Franco, R. S., Kakuda, L., Cadioli, G. F., Costa, G. M. D., Bouvret, E. (2021). Oral Supplementation with Hydrolyzed Fish Cartilage Improves the Morphological and Structural Characteristics of the Skin: A Double-Blind, Placebo-Controlled Clinical Study. Molecules, 26(16), 4880.

Chotphruethipong, L., Binlateh, T., Hutamekalin, P., Aluko, R. E., Tepaamorndech, S., Zhang, B., & Benjakul, S. (2021). Impact of Hydrolyzed Collagen from Defatted Sea Bass Skin on Proliferation and Differentiation of Preosteoblast MC3T3-E1 Cells. Foods, 10(7), 1476.

Lee, J.-H., Bridge, J. E., Clark, D. R., Stewart, C. E., & Erskine, R. M. (2023). Collagen supplementation augments changes in patellar tendon properties in female soccer players. Frontiers in Physiology, 14.

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