Methylsulfonylmethane (MSM) in Joint Health

Methylsulfonylmethane (MSM) is a dietary supplement increasingly recognized for its potential benefits in joint health. Derived from natural sources, MSM has gained attention for its role in managing osteoarthritis and enhancing mobility in individuals with joint issues.

MSM is understood to provide sulfur, crucial for maintaining healthy joint cartilage. Its anti-inflammatory properties help reduce joint inflammation, a key factor in osteoarthritis and related joint disorders. Furthermore, MSM’s antioxidant effects contribute to protecting joint tissues from damage.

Recent clinical trials reveal MSM’s efficacy in improving symptoms of osteoarthritis. For instance, a study by Pagonis et al. (2014) demonstrated significant improvements in physical symptoms among osteoarthritis patients treated with MSM. These findings are supported by another research conducted by Xu et al. (2015), highlighting MSM’s role in improving joint function and quality of life in aging populations experiencing joint degeneration.

Beyond joint health, MSM is noted for its positive effects on mobility. This was illustrated in a randomized, double-blind trial, which showed MSM supplementation leading to improved performance in daily living activities, as reported by Pagonis et al. (2014). Such findings underscore MSM’s potential in enhancing overall physical function in individuals with joint issues.

MSM’s safety profile is well-established in the literature. Studies, such as the one by Bloomer et al. (2015), indicate that MSM is generally safe and well-tolerated when used in recommended dosages. This aspect is crucial, considering the long-term nature of joint health management.

MSM offers potential anti-inflammatory and antioxidant benefits, along with enhancing mobility and quality of life. Its safety profile further makes it a viable option for individuals seeking natural interventions for joint health.


Pagonis, T., Givissis, P., Kritis, A., & Christodoulou, A. (2014). The Effect of Methylsulfonylmethane on Osteoarthritic Large Joints and Mobility. International Journal of Orthopaedics.
DOI: 10.6051/IJO.V1I1.745.

Xu, G., Zhou, T., Gu, Y., Wang, Q., Shariff, M., Gu, P., Nguyen, T., Shi, R., & Rao, J. (2015). Evaluation of the Effect of Mega MSM on Improving Joint Function in Populations Experiencing Joint Degeneration. International Journal of Biomedical Science: IJBS.

Bloomer, R., Melcher, D., & Benjamin, R. (2015). Serum MSM Concentrations Following One Month of MSM Treatment in Healthy Men. Clinical Pharmacology & Biopharmaceutics.
DOI: 10.4172/2167-065X.1000135

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