The review examines the combined effects of these fat-soluble vitamins, both essential in calcium metabolism. Vitamin D is crucial for producing vitamin K-dependent proteins, which need vitamin K for their activation. This synergistic interaction is particularly beneficial for bone and cardiovascular health. The review brings together evidence from animal and human studies, showing that optimal levels of both vitamins can significantly improve bone health, especially in postmenopausal women, and potentially benefit cardiovascular health. Although fewer studies have focused on cardiovascular outcomes, the existing research suggests that taking these vitamins together may be more effective than consuming either alone.
The article reinforces the importance of a balanced diet rich in vitamins D and K, found in foods like vegetables and fermented dairy, to maintain bone and cardiovascular health. The emerging understanding of the powerful combination of these vitamins underscores the need for joint supplementation in certain populations, particularly for enhancing bone health and potentially offering cardiovascular benefits.
Original Publication:
van Ballegooijen, A. J., Pilz, S., Tomaschitz, A., Grübler, M. R., & Verheyen, N. (2017). The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review. International Journal of Endocrinology, 2017, Article ID 7454376.
https://doi.org/10.1155/2017/7454376
